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Peptide record

TPDB63740

penetratin Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB63740
penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 18-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKGG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C108H174N36O22S1
ADCEHLPSTYV
K
2360.86
12.72
7
0
6
+7
3.50
-1.583
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
4.66
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C108H174N36O22S1 sequence-only estimate (linear, free termini)
2360.86 sequence-only estimate (linear, free termini)
12.72 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
3.50 sequence-only estimate (linear, free termini)
-1.583 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Porcine Eyes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Rebamipide
PM-COOH uptake was improved
Endocytosis
Ex vivo
CCTTSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Labcyte Cornea-Model24

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
YG carboxylate polystyrene microspheres (PM-COOH)
PNT enhanced the uptake of rebamipide
Endocytosis
In vitro
CCCCCCGGGCCSSCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Mannosyl erythritol lipid (MEL)-based peptide linker modified Texas red-DHPE-encapsulated LPNVs
Endoplasmic Reticulum
The fluorescence images of the LPNVPnt-(40 mM)-treated HEK-293T cells and found that a large number of NVs had entered the cells with 10 wt% of PEO-b-PCL-b-PEO.
Endocytosis
In vitro
CCCCCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
CCSCCSSCCCSSSCC
Additional Detail Fields 1 fields
CCTTSSCCCCC CCCCCCGGGCCSSCCCCC CCCCCCCCC CCSCCSSCCCSSSCC