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Peptide record

TPDB63739

Pen Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB63739
Pen
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RQIKIWFQNRRMKWKKGC-NH2
Physicochemical Analysis
C109H176N36O22S2
ADEHLPSTYV
K
2406.94
12.16
7
0
6
+7
2.06
-1.422
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
457.01
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
2
Q
1
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
18
C109H176N36O22S2
2406.94
12.16
+7
2.06
-1.422
Amidation
L
Cationic
Linear
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Tumor-xenografted nude mice
Tumor-xenografted nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (Alexa660)
Accumulations were only slightly different from that of the control GC peptide in tumors
In vivo
CCSSSCCSCCCCCCCCCC
Additional Detail Fields 1 fields
CCSSSCCSCCCCCCCCCC