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Peptide record

TPDB63738

PN251 (SEQ ID NO: 54) Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB63738
PN251 (SEQ ID NO: 54)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RQIKIWFQNRRMKWKKDIMGEWGNEIFGAIAGFLG-NH2
Physicochemical Analysis
C196H299N55O46S2
CHPSTYV
GI
4225.99
10.95
7
3
16
+4
1.86
-0.463
72.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
390.44
4
Residue Composition
number
2
A
3
R
2
N
1
D
0
C
2
E
2
Q
5
G
0
H
5
I
1
L
4
K
2
M
3
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 1 C: 0 E: 2 Q: 2 G: 5 H: 0 I: 5 L: 1 K: 4 M: 2 F: 3 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
35
C196H299N55O46S2
4225.99
10.95
+4
1.86
-0.463
Amidation
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCCCCSSCCCCCHHHHHSCSCCSCSIIIIIHHHCC
Additional Detail Fields 1 fields
CCCCCSSCCCCCHHHHHSCSCCSCSIIIIIHHHCC