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Peptide record

TPDB63711

pAntp (43-50) Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB63711
pAntp (43-50)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation (Labeled with Biotinyl-beta-Alanine)
Sequence
RQIKIWFQ-NH2
Physicochemical Analysis
C54H83N15O11
ANDCEGHLMPSTYV
QI
1118.35
11.49
2
0
4
+2
-0.64
-0.562
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
491.80
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C54H83N15O11
1118.35
11.49
+2
-0.64
-0.562
Amidation
L
Linear
Biotinylation (Labeled with Biotinyl-beta-Alanine)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCat/ A549 cells

Source & Reference

CPPsite3.0
CPPsite3
US 7153931

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Biotin
Probably Cytosol and nucleus, nucleoi
Low (15% relative to (pAntp) (43-58))
Non-endocytic mechanism
In vitro
CCSSCCCC
Additional Detail Fields 1 fields
CCSSCCCC