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Peptide record

TPDB63694

Ala47 substitution mutant of pAntp (43-58) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63694
Ala47 substitution mutant of pAntp (43-58)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation (Labeled with Biotinyl-beta-Alanine)
Sequence
RQIKAWFQNRRMKWKK-NH2
Physicochemical Analysis
C101H162N34O20S1
DCEGHLPSTYV
K
2204.67
12.72
7
0
6
+7
2.43
-1.900
30.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
498.94
3
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C101H162N34O20S1
2204.67
12.72
+7
2.43
-1.900
Amidation
L
Amphipathic
Linear
Biotinylation (Labeled with Biotinyl-beta-Alanine)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)/C/1=N/[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=C(C)/C/2=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCat/ A549 cells

Source & Reference

CPPsite3.0
CPPsite3
US 7153931

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Biotin
Probably Cytosol and nucleus, nucleoi
Medium (55% relative to (pAntp) (43-58))
Non-endocytic mechanism
In vitro
CCCHHHHHTCCBTTBC
Additional Detail Fields 1 fields
CCCHHHHHTCCBTTBC