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Peptide record

TPDB63693

Ala46 substitution mutant of pAntp (43-58) Cell-penetrating Peptides modified_plain modified
16 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63693
Ala46 substitution mutant of pAntp (43-58)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia
modified_plain
Yes
A 16-aa modified cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation (Labeled with Biotinyl-beta-Alanine)
Sequence
RQIAIWFQNRRMKWKK-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
16 reviewed residue count
Amidation Activity
L Activity
Amphipathic Activity
Linear Activity
Biotinylation (Labeled with Biotinyl-beta-Alanine) Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCat/ A549 cells

Source & Reference

CPPsite3.0
CPPsite3
US 7153931

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Biotin
Probably Cytosol and nucleus, nucleoi
Medium (50% relative to (pAntp) (43-58))
Non-endocytic mechanism
In vitro
CCCCCSSSCCCBTTBC
Additional Detail Fields 1 fields
CCCCCSSSCCCBTTBC