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Peptide record

TPDB63683

L-SPA Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB63683
L-SPA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
RPKPWQWFWLL-NH2
Physicochemical Analysis
C81H109N19O13
ANDCEGHIMSTYV
W
1556.88
11.49
2
0
6
+2
-4.52
-0.673
70.91
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1059.81
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
1
K
0
M
1
F
2
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 1 M: 0 F: 1 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
11
C81H109N19O13
1556.88
11.49
+2
-4.52
-0.673
Amidation
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
SPA exhibited significantly greater stability in serum than L-SPA
Clathrin- and caveolin-mediated endocytosis and direct translocation
In vitro
CCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCC