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Peptide record

TPDB63679

Ara27 (NR-FGF2) Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB63679
Ara27 (NR-FGF2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RNQRKTVRCFRCRQAGHWISDCRLKSK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C139H234N54O36S3
EMPY
R
3333.91
11.78
10
1
6
+8
4.48
-1.293
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5625
1.69
9
Residue Composition
number
1
A
6
R
1
N
1
D
3
C
0
E
2
Q
1
G
1
H
1
I
1
L
3
K
0
M
1
F
0
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 1 D: 1 C: 3 E: 0 Q: 2 G: 1 H: 1 I: 1 L: 1 K: 3 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
27 reviewed residue count
C139H234N54O36S3 sequence-only estimate (linear, free termini)
3333.91 sequence-only estimate (linear, free termini)
11.78 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
4.48 sequence-only estimate (linear, free termini)
-1.293 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hdf

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
FITC and hFGF2
Ara27-FITC translocated into the cells more than Tat-FITC
Clathrin and caveolae mediated endocytosis
In vitro
CCCCCSSSTTCSSCSSTTSCC
Additional Detail Fields 1 fields
CCCCCSSSTTCSSCSSTTSCC