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Peptide record

TPDB63661

CPP33 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63661
CPP33
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Chimeric lipopepsomes (CLP)
Sequence
RLWMRWYSPRTRAYGC
Physicochemical Analysis
C95H140N30O21S2
NDEQHIKFV
R
2102.47
11.12
4
0
7
+4
-2.81
-0.994
30.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
664.93
5
Residue Composition
number
1
A
4
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
16
C95H140N30O21S2
2102.47
11.12
+4
-2.81
-0.994
Addition of Cysteine
Chimeric lipopepsomes (CLP)
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells ,MDA-MB-231 And Smmc-7721 Cells

Assay & Model

A549 tumor–bearing nude mice
A549 tumor–bearing nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Polo-like kinase 1 specific siRNA (siPLK1)
A549 human lung cancer cells had significantly higher cellular uptake of CPP33-CLP than other cancer cells including MDA-MB-231 and SMMC-7721 cells
Dynamin-dependent and clathrin/micropinocytosis/caveolae-independent pathway
In vitro and in vivo
CCCCTTGGGCCCC
Additional Detail Fields 1 fields
CCCCTTGGGCCCC