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Peptide record

TPDB63651

α-NLS-C Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB63651
α-NLS-C
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: α-pheromon N-terminal: Conjugated with TAMRA
Sequence
RLWHWLQLKPGQPMYWRQPKSKRKVRR
Physicochemical Analysis
C165H260N54O33S1
ANDCEIFT
R
3560.28
12.59
10
0
9
+9
3.87
-1.641
54.07
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17990
505.30
5
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
3
Q
1
G
1
H
0
I
3
L
4
K
1
M
0
F
3
P
1
S
0
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 1 H: 1 I: 0 L: 3 K: 4 M: 1 F: 0 P: 3 S: 1 T: 0 W: 3 Y: 1 V: 1
Chemical Descriptors
27
C165H260N54O33S1
3560.28
12.59
+9
3.87
-1.641
Free
α-pheromon
L
Linear
Conjugated with TAMRA
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Cerevisiae (Mata And Matα ), Hek293T , Hek293T-Nep And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
TAMRA dye
MATa cells exposed to the α-NLS-C peptide presented more selectivity towards MATα cells than NLS-α-CE and chimera peptides.
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC