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Peptide record

TPDB63636

1b Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63636
1b
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with 5(6)-Carboxyfluorescein
Sequence
RLLRLLRLL-NH2
Physicochemical Analysis
C54H104N18O10
ANDCEQGHIKMFPSTWYV
L
1165.53
12.70
3
0
6
+3
-0.93
1.033
260.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H104N18O10
1165.53
12.70
+3
-0.93
1.033
Amidation
L
Cationic
Linear
Conjugation with 5(6)-Carboxyfluorescein
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophor [5(6)-CF]
Nucleus
Cellular uptake of peptide with 24- and 36-h incubation period was markedly lower than that with the 2-h incubation
In vitro
CCCCGGGCC
Additional Detail Fields 1 fields
CCCCGGGCC