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Peptide record

TPDB63632

CPP28 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63632
CPP28
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RLIMRIYAPTTRRYG
Physicochemical Analysis
C83H139N27O20S1
NDCEQHKFSWV
R
1867.25
11.94
4
0
7
+4
0.52
-0.500
84.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
159.59
4
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
0
K
1
M
0
F
1
P
0
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C83H139N27O20S1
1867.25
11.94
+4
0.52
-0.500
L
Linear
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Many Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF

Assay & Model

NOD-SCID mice model of xenograft human tumour cells
NOD-SCID mice model of xenograft human tumour cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
In vitro and in vivo
CCCCCCCCCCCCCCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Homing
Osteosarcoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems
2012
Eisaku Kondo et al. Nat Commun. 2012 Jul 17:3:951.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U2OS
7-week-old NOD-SCID mouse
mRNA display library
Additional Detail Fields 3 fields
CCCCCCCCCCCCCCC
U2OS
7-week-old NOD-SCID mouse