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Peptide record

TPDB63622

P2 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB63622
P2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-(Acp)--labelled
Sequence
RKRRQTSMTDFYHSKRRLIFSKRK
Physicochemical Analysis
C136H229N49O34S1
ANCEGPWV
R
3126.68
12.42
11
1
6
+9
7.96
-1.754
32.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
47.65
7
Residue Composition
number
0
A
6
R
0
N
1
D
0
C
0
E
1
Q
0
G
1
H
1
I
1
L
4
K
1
M
2
F
0
P
3
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 1 K: 4 M: 1 F: 2 P: 0 S: 3 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
24
C136H229N49O34S1
3126.68
12.42
+9
7.96
-1.754
Free
FITC-(Acp)--labelled
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7, A549 , HeLa , HEPG2, RAW264.7 And Rat T6 Cells Primary Cultured Cells, Liver Cells And Hepatic Parenchymal Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
HaloTag
Nucleus
P2 has higher penetration efficiency than MT23 but lower than TAT and hPP10, and Dot1l. Also penetration in HeLa cells were higher than MCF7, HepG2, A549 and HSC-T6.
Endocytosis pathways (including receptor-mediated endocytosis)
In vitro
CCCCCCCHHHHSSCSSCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCHHHHSSCSSCCCCCCC