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Peptide record

TPDB63621

DMAP1459-467 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63621
DMAP1459-467
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
RKRRESASSSSSVKKAKKP-NH2
Physicochemical Analysis
C87H161N33O28
NDCQGHILMFTWY
S
2117.44
12.17
8
1
3
+7
10.36
-1.847
25.79
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
6
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
6
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 6 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C87H161N33O28
2117.44
12.17
+7
10.36
-1.847
Amidation
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, PC3, And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-conjugated
Fluorescent signal was above control
In vitro
CCCCCCSSCSCCC
Additional Detail Fields 1 fields
CCCCCCSSCSCCC