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Peptide record

TPDB63619

0084_SpyT Cell-penetrating Peptides standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB63619
0084_SpyT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 50-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKQKSLQTKLAENPPVPRKKRQSRPRWKQWLQKGASAHIVMVDAYKPTKG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C261H434N84O67S1
CF
K
5852.90
11.96
15
2
15
+12
2.93
-1.338
56.60
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
2.13
12
Residue Composition
number
4
A
5
R
1
N
1
D
0
C
1
E
5
Q
2
G
1
H
1
I
3
L
9
K
1
M
0
F
5
P
3
S
2
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 5 N: 1 D: 1 C: 0 E: 1 Q: 5 G: 2 H: 1 I: 1 L: 3 K: 9 M: 1 F: 0 P: 5 S: 3 T: 2 W: 2 Y: 1 V: 3
Chemical Descriptors
50 reviewed residue count
C261H434N84O67S1 sequence-only estimate (linear, free termini)
5852.90 sequence-only estimate (linear, free termini)
11.96 sequence-only estimate (linear, free termini)
+12 sequence-only estimate (linear, free termini)
2.93 sequence-only estimate (linear, free termini)
-1.338 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Or T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
β-lactamase protein and CCF2-AM cell-permeable dye
Cytoplasm
In vitro
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC