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Peptide record

TPDB63618

Cell-penetrating Peptides standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB63618
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 33-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
RKQKSLQTKLAENPPVPRKKRQSRPRWKQWLQK
Physicochemical Analysis
C184H311N63O45
DCGHIMFY
K
4125.89
12.60
12
1
7
+11
13.04
-2.042
47.27
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
266.61
9
Residue Composition
number
1
A
5
R
1
N
0
D
0
C
1
E
5
Q
0
G
0
H
0
I
3
L
7
K
0
M
0
F
4
P
2
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 0 C: 0 E: 1 Q: 5 G: 0 H: 0 I: 0 L: 3 K: 7 M: 0 F: 0 P: 4 S: 2 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
33
C184H311N63O45
4125.89
12.60
+11
13.04
-2.042
Free
EBD_S11 fusion proteins
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid
Cytoplasm
Dose-dependent uptake
In vitro
CCCCTTSCSSCCCCCCCCSCCCCCCCCCBCSSCBCCCCCCCCSSCCC
Additional Detail Fields 1 fields
CCCCTTSCSSCCCCCCCCSCCCCCCCCCBCSSCBCCCCCCCCSSCCC