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Peptide record

TPDB63612

P14(L) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63612
P14(L)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKKRWFRRRRPKWKK
Physicochemical Analysis
C102H170N40O16
ANDCEQGHILMSTYV
R
2212.73
13.11
11
0
3
+11
5.43
-3.140
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
497.12
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
1
F
1
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C102H170N40O16
2212.73
13.11
+11
5.43
-3.140
Free
L
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Pluc705 Cells , RAW264.7, Hepg2, And MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
PNA705, tetramethylrhodamine (TAMRA) and GFP11 peptide
Cytoplasm
Increased luciferase over background by more than 400-fold and TAMRA delivery follows P17 >>P11 = P14 > P40 = Arg9 > tat = penetratin
Direct translocation and endocytosis
In vitro
CCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCC