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Peptide record

TPDB63610

DPV3/10 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB63610
DPV3/10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Cys addition
Sequence
RKKRRRESRRARRSPRHL
Physicochemical Analysis
C97H181N49O23
NDCQGIMFTWYV
R
2401.82
12.95
12
1
2
+10
12.23
-2.922
27.22
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
9
R
0
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
1
L
2
K
0
M
0
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 2 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C97H181N49O23
2401.82
12.95
+10
12.23
-2.922
Free
L
Linear
Cys addition
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (PO and IgG)
Cytoplasm
Energy-dependent endocytic process involving cell membrane lipid rafts
In vitro
CCCCCGGGGTCCCCCCC
Additional Detail Fields 1 fields
CCCCCGGGGTCCCCCCC