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Peptide record

TPDB63606

H4 Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB63606
H4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKKRRR
Physicochemical Analysis
C36H74N20O7
ANDCEQGHILMFPSTWYV
R
899.11
12.88
6
0
0
+6
5.22
-4.300
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C36H74N20O7
899.11
12.88
+6
5.22
-4.300
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
EGFP protein
Cytoplasm and nucleus
EGFP-H3 and EGFP-H4 showed higher cellular uptake than that of EGFP-HBD, EGFP-H1 and EGFP-H5
In vitro
CCCCCC
Additional Detail Fields 1 fields
CCCCCC