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Peptide record

TPDB63600

DP-BoNT/A Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB63600
DP-BoNT/A
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Dansyl tagged
Sequence
RKKRRQRRRGYKKKKKKKKKKYGRKKRRQRRR
Physicochemical Analysis
C188H354N84O37
ANDCEHILMFPSTWV
K
4383.42
12.89
26
0
2
+26
22.88
-3.719
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
67.98
4
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
2
Q
2
G
0
H
0
I
0
L
14
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 0 L: 0 K: 14 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
32
C188H354N84O37
4383.42
12.89
+26
22.88
-3.719
Free
Dansyl tagged
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih-3 T3 Cells

Assay & Model

Mice
Mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Botulinum neurotoxin (BoNT)
Cell Membrane, Cytoplasm and Nuclear Membrane
Time-dependent internalization
In vitro and in vivo
CCCCCCCTTTSSCCSCC
Additional Detail Fields 1 fields
CCCCCCCTTTSSCCSCC