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Peptide record

TPDB63597

R23IT (TAT + AF) Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB63597
R23IT (TAT + AF)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: GGGG as a Linker
Sequence
RKKRRQRRRGGGGVTDFGVFVEI
Physicochemical Analysis
C115H196N44O30
ANCHLMPSWY
R
2675.10
12.41
8
2
6
+6
8.50
-1.100
54.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
1
D
0
C
1
E
1
Q
5
G
0
H
1
I
0
L
2
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 5 H: 0 I: 1 L: 0 K: 2 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C115H196N44O30
2675.10
12.41
+6
8.50
-1.100
Free
GGGG as a Linker
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bt474 Cells S. Aureus, Mrsa, And B. Cereus

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Amyloidogenic fragment (AF) at C terminal
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC