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Peptide record

TPDB63593

TAT-F9-KOV2 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB63593
TAT-F9-KOV2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKKRRQRRRGGAAKLPFRCFAAFC
Physicochemical Analysis
C125H211N49O26S2
NDEHIMSTWYV
R
2880.48
12.53
10
0
8
+10
4.58
-1.029
32.92
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
4.34
3
Residue Composition
number
4
A
7
R
0
N
0
D
2
C
0
E
1
Q
2
G
0
H
0
I
1
L
3
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 7 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 3 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C125H211N49O26S2
2880.48
12.53
+10
4.58
-1.029
Free
L
Cationic
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)/N=C/C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)/N=C/C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, U251Mg, H157, H460 Bacterial Cell =E. Coli, Klebsiella Pneumoniae, Pseudomonas Aeruginosa, Staphylococcus Aureus, Methicillin-Resistant Staphylococcus Aureus, Enterococcus Faecium, Candida Albicans

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
F9-kunitzin-OV2
20–25-fold increase in antiproliferative capacity against human lung cancer (H157, H460) cell lines compared with TAT-KOV2
In vitro
CCCCCCSSSSSCCCSSSCSSCCCCCCCCSSCCSSSSCCCCSCSSCCCSCSSSCCSSSCSSSSCCCCSSCCSCSSCCCC
Additional Detail Fields 1 fields
CCCCCCSSSSSCCCSSSCSSCCCCCCCCSSCCSSSSCCCCSCSSCCCSCSSSCCSSSCSSSSCCCCSSCCSCSSCCCC