Back to search

Peptide record

TPDB63591

TAT Cell-penetrating Peptides modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63591
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 10-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Small molecule(UNC7938) N-terminal: Conjugated with Tetramethylrhodamine (TMR)
Sequence
RKKRRQRRRG-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
10 reviewed residue count
Amidation Activity
Small molecule(UNC7938) Activity
L Activity
Cationic Activity
Linear Activity
Conjugated with Tetramethylrhodamine (TMR) Activity
N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drg-F11, MDA-MB-231, HeLa, Neuro-2A, Mch58, Cos-7, Jurkat, Hek293F

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
TMR dye
Nucleolar And Cytoplasm
UNC7938-induced cell penetration was overall more efficient for dfTAT and D-dfTAT than for TMR-TAT and r11
Endocytosis
In vitro
CCCCSSCCCCCTTHHHHTC
Additional Detail Fields 1 fields
CCCCSSCCCCCTTHHHHTC