Back to search

Peptide record

TPDB63591

TAT Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63591
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Small molecule(UNC7938) N-terminal: Conjugated with Tetramethylrhodamine (TMR)
Sequence
RKKRRQRRRG-NH2
Physicochemical Analysis
C55H109N31O12
ANDCEHILMFPSTWYV
R
1396.67
13.10
8
0
0
+8
7.43
-3.870
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C55H109N31O12
1396.67
13.10
+8
7.43
-3.870
Amidation
Small molecule(UNC7938)
L
Cationic
Linear
Conjugated with Tetramethylrhodamine (TMR)
N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drg-F11, MDA-MB-231, HeLa, Neuro-2A, Mch58, Cos-7, Jurkat, Hek293F

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
TMR dye
Nucleolar And Cytoplasm
UNC7938-induced cell penetration was overall more efficient for dfTAT and D-dfTAT than for TMR-TAT and r11
Endocytosis
In vitro
CCCCSSCCCCCTTHHHHTC
Additional Detail Fields 1 fields
CCCCSSCCCCCTTHHHHTC