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Peptide record

TPDB63582

Tat-C-RP7 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63582
Tat-C-RP7
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RKKRRQRRRCRPARPAR
Physicochemical Analysis
C90H171N47O19S1
NDEGHILMFSTWYV
R
2247.71
12.95
11
0
2
+11
10.17
-2.876
11.76
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
9
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C90H171N47O19S1
2247.71
12.95
+11
10.17
-2.876
Free
L
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs And U87-Luc-Mcherry Cells

Assay & Model

Female Balb/c-nu mice (7–8 weeks old)
Female Balb/c-nu mice (7–8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
NRP1 targeting peptide RP7 and FITC dye
Cytoplasm and nucleus
Tat-C-RP7 was a more potent penetrating peptide than Tat
In vitro and in vivo
CCCSCCCCCCCCCSSCC
Additional Detail Fields 1 fields
CCCSCCCCCCCCCSSCC