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Peptide record

TPDB63581

TAT-AT7 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63581
TAT-AT7
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled PEI polymer (PPTA)
Sequence
RKKRRQRRRCATWLPPR
Physicochemical Analysis
C96H170N42O20S1
NDEGHIMFSYV
R
2264.74
12.80
9
0
3
+9
6.45
-2.324
28.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
242.85
3
Residue Composition
number
1
A
7
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
1
L
2
K
0
M
0
F
2
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 2 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C96H170N42O20S1
2264.74
12.80
+9
6.45
-2.324
Free
FITC-labeled PEI polymer (PPTA)
L
Cationic
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bend3 Cells And HUVEC/U87 Cell Coculture Model

Assay & Model

Orthotopic U87 glioma-bearing nude mice model.
Orthotopic U87 glioma-bearing nude mice model.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
pVAXI-En and pEGFP-N1 plasmids
Lysosomes
PPTA/pVAXI-En and PPT/pVAXI-En displayed a superior ability to traverse the BBB and BTB compared with that of PEI/pVAXI-En and PPA/pVAXI-En.
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC