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Peptide record

TPDB63581

TAT-AT7 Cell-penetrating Peptides modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63581
TAT-AT7
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 17-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled PEI polymer (PPTA)
Sequence
RKKRRQRRRCATWLPPR
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
17 reviewed residue count
Free Activity
FITC-labeled PEI polymer (PPTA) Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bend3 Cells And HUVEC/U87 Cell Coculture Model

Assay & Model

Orthotopic U87 glioma-bearing nude mice model.
Orthotopic U87 glioma-bearing nude mice model.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
pVAXI-En and pEGFP-N1 plasmids
Lysosomes
PPTA/pVAXI-En and PPT/pVAXI-En displayed a superior ability to traverse the BBB and BTB compared with that of PEI/pVAXI-En and PPA/pVAXI-En.
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC