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Peptide record

TPDB63580

TAT Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63580
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKKRRQRRRC
Physicochemical Analysis
C56H111N31O12S1
ANDEGHILMFPSTWYV
R
1442.76
12.71
8
0
0
+8
7.18
-3.580
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C56H111N31O12S1
1442.76
12.71
+8
7.18
-3.580
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs And Hce Cell Line

Assay & Model

Brown Norway (BN) male rats
Brown Norway (BN) male rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
(PLGA) nanoparticles (NPs) labelled with Nile red
Nucleus
The red fluorescence intensity of the NPs at 6 h followed the order of iRGD–TAT-Nile red NP > TAT-Nile red-NP and iRGD-Nile red NP > mPEG–PLGA-Nile red-NP.
In vitro and in vivo
CCSSSCCCCCCC
Additional Detail Fields 1 fields
CCSSSCCCCCCC