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Peptide record

TPDB63573

TAT Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB63573
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RKKRQRRR
Physicochemical Analysis
C47H94N26O10
ANDCEGHILMFPSTWYV
R
1183.43
13.01
7
0
0
+7
6.61
-4.225
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C47H94N26O10
1183.43
13.01
+7
6.61
-4.225
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Dcs , Splenocytes From C57Bl/6 Mice

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
FITC-dye and gp100 peptide to the N terminus
Cytosol
18-fold increase with Tat in dendritic cells
Endocytosis
In vitro and in vivo