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Peptide record

TPDB63568

hBCPP Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63568
hBCPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 10-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
RKKNPNCRRH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C52H93N25O13S1
ADEQGILMFSTWYV
R
1308.53
12.13
6
0
0
+5
7.25
-3.060
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
3
R
2
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10 reviewed residue count
C52H93N25O13S1 sequence-only estimate (linear, free termini)
1308.53 sequence-only estimate (linear, free termini)
12.13 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
7.25 sequence-only estimate (linear, free termini)
-3.060 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human mesenchymal stem cell (hMSC) line

Assay & Model

Female Lewis rats
Female Lewis rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Peptide (Smurf1-binding peptide)
Cytoplasm and nucleus
Higher uptake efficiency
In vitro and in vivo
CBTTTBCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sf9 And Rp-Hzgut-Aw1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
STAR635P fluorophore
Lysosomes
Rapid uptake of CPP through endosomes as Fluorescent vesicles were observed in as little as 20 min.
Endocytosis
In vitro and ex vivo
CCCCCSSCGGGTCCCC
Additional Detail Fields 1 fields
CBTTTBCCC CCCCCSSCGGGTCCCC