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Peptide record

TPDB63566

PAF96 Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB63566
PAF96
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 6-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RKKAAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C27H53N11O7
NDCEQGHILMFPSTWYV
A
643.79
11.64
3
0
3
+3
3.43
-1.150
50.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6 reviewed residue count
C27H53N11O7 sequence-only estimate (linear, free termini)
643.79 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
3.43 sequence-only estimate (linear, free termini)
-1.150 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Neurospora crassa WT 74- OR23-1VA matA strain, Aspergillus fumigatus CEA10 strain,Penicillium digitatum strain PHI26 and strains of Saccharomyces cerevisiae (BY4741,Y04007,Y01750 and Y03125)
Neurospora crassa WT 74- OR23-1VA matA strain, Aspergillus fumigatus CEA10 strain,Penicillium digitatum strain PHI26 and strains of Saccharomyces cerevisiae (BY4741,Y04007,Y01750 and Y03125)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (TMR)
Bound to cell envelope only
In vitro
CBTTBC
Additional Detail Fields 1 fields
CBTTBC