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Peptide record

TPDB63561

Peptide 8 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63561
Peptide 8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
RIRMIQNLIKKT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C66H124N22O16S1
ADCEGHFPSWYV
I
1513.91
12.42
4
0
5
+4
2.80
-0.442
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
3
I
1
L
2
K
1
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 1 K: 2 M: 1 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C66H124N22O16S1 sequence-only estimate (linear, free termini)
1513.91 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.80 sequence-only estimate (linear, free termini)
-0.442 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HIG-82 cells

Source & Reference

CPPsite3.0
CPPsite3
US 6881825

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Phages
In vitro
CCTTHHHHTTCC
Additional Detail Fields 1 fields
CCTTHHHHTTCC