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Peptide record

TPDB63560

DS4.3 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63560
DS4.3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RIMRILRILKLAR
Physicochemical Analysis
C74H142N26O14S1
NDCEQGHFPSTWYV
R
1652.17
12.88
5
0
8
+5
1.22
0.515
187.69
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
3
L
1
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 3 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C74H142N26O14S1
1652.17
12.88
+5
1.22
0.515
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CT26 mouse colon cancer cells, HeLa and Hep3B cells

Assay & Model

Male Balb/c mice
Male Balb/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Peptide (Mitochondrial Target Domain of NOXA)
Higher uptake efficiency
In vitro and in vivo
CCCCTHHHHTSCC
Additional Detail Fields 1 fields
CCCCTHHHHTSCC