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Peptide record

TPDB63544

PTD Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63544
PTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 16-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
Sequence
RHIKIWFQNRRMKWKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C105H167N35O19S1
ADCEGLPSTYV
K
2255.76
12.72
8
0
6
+7
4.00
-1.712
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
4.88
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C105H167N35O19S1 sequence-only estimate (linear, free termini)
2255.76 sequence-only estimate (linear, free termini)
12.72 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
4.00 sequence-only estimate (linear, free termini)
-1.712 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hpdls, Mms, Scc-1, Gmsc, Agk And Obc Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
GFP protein
Periphery And Cytosol
In vitro
CCCCCSCCSSSSCCCCCC
Additional Detail Fields 1 fields
CCCCCSCCSSSSCCCCCC