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Peptide record

TPDB63535

PN404 (SEQ ID NO: 91) Cell-penetrating Peptides standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB63535
PN404 (SEQ ID NO: 91)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 36-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RGSRRAVTRAQRRDGRRRRRSRRESYSVYVYRVLRQ-NH2
Physicochemical Analysis
C188H327N83O51
NCHIKMFPW
R
4566.19
12.58
15
2
10
+13
13.80
-1.831
48.61
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
4470
97.89
10
Residue Composition
number
2
A
15
R
0
N
1
D
0
C
1
E
2
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
4
S
1
T
0
W
3
Y
4
V
Amino Acid Distribution
A: 2 R: 15 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 4 T: 1 W: 0 Y: 3 V: 4
Chemical Descriptors
36
C188H327N83O51
4566.19
12.58
+13
13.80
-1.831
Amidation
L
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

LacZ cells and murine taile fibroblast cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCCSTTCCSSCCCCCSGGGGSCCCCCCSSCCCSSCC
Additional Detail Fields 1 fields
CCCSTTCCSSCCCCCSGGGGSCCCCCCSSCCCSSCC