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Peptide record

TPDB63533

ParasinR Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63533
ParasinR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RGRGRQGGRVRARWRTRSS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C90H159N45O24
NDCEHILKMFPY
R
2255.54
13.25
8
0
3
+8
6.44
-2.016
20.53
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
2.44
4
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
19 reviewed residue count
C90H159N45O24 sequence-only estimate (linear, free termini)
2255.54 sequence-only estimate (linear, free termini)
13.25 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
6.44 sequence-only estimate (linear, free termini)
-2.016 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli Strain Carolina #25922

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Higher arginine content increased permeabilization for parasin
In vitro
CEEEEEESSSSSSEEEECC
Additional Detail Fields 1 fields
CEEEEEESSSSSSEEEECC