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Peptide record

TPDB63530

SynB1-ELP-H1 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63530
SynB1-ELP-H1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
C-terminal: Conjugation with ELP-Rho
Sequence
RGGRLSYSRRRFSTSTGRA
Physicochemical Analysis
C89H151N37O27
NDCEQHIKMPWV
R
2171.41
12.70
6
0
4
+6
2.89
-1.353
25.79
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
68.62
7
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
4
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 4 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
19
C89H151N37O27
2171.41
12.70
+6
2.89
-1.353
Conjugation with ELP-Rho
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human U-87-MG and D54 glioma cells along with the rat C6 glioma cells

Assay & Model

Female Sprague Dawley rats
Female Sprague Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Peptide (Rhodamine labeled ELP)
Significantly enhancing brain tumor deposition of the ELP carrier
In vitro and in vivo
CCSCCCCCCCCSCCCGGGC
Additional Detail Fields 1 fields
CCSCCCCCCCCSCCCGGGC