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Peptide record

TPDB63527

SynB5 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63527
SynB5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with NBD and TAMRA
Sequence
RGGRLAYLRRRWAVLGR
Physicochemical Analysis
C91H154N36O19
NDCEQHIKMFPST
R
2056.45
12.70
6
0
8
+6
0.15
-0.659
97.65
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
339.91
1
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
17
C91H154N36O19
2056.45
12.70
+6
0.15
-0.659
Free
L
Antimicrobial
Linear
Conjugation with NBD and TAMRA
N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

K562 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Antimicrobial
Protein derived
Fluorophore (NBD and TAMRA)
Endocytic vesicles
Lower than pAntp-(43–58)
Adsorptive-mediated endocytic process
In vitro
CCTTSGGGGGGTCCSCC
Additional Detail Fields 1 fields
CCTTSGGGGGGTCCSCC