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Peptide record

TPDB63526

RGE Blood-Brain Barrier Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB63526
RGE
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Sequence
RGERPPR
Physicochemical Analysis
C35H62N16O10
ANDCQHILKMFSTWYV
R
866.98
12.10
3
1
0
+2
5.36
-2.943
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C35H62N16O10
866.98
12.10
+2
5.36
-2.943
Free
L
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, Calu-3, 4T1 And 4T1 Cells

Assay & Model

MDA-MB-231 breast tumor xenograft mouse model of BALB/c nude mice (female, 4–5 weeks, 18–22 g)
MDA-MB-231 breast tumor xenograft mouse model of BALB/c nude mice (female, 4–5 weeks, 18–22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
Gambogic acid(GA), nanostructured lipid carrier(NLC) , coumarin-7
Intracellular quantitative fluorescence intensity of coumarin-6-NLC-RGE is 342.34 ± 51.75
Endocytosis
In-vitro, in-vivo and ex vivo
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC