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Peptide record

TPDB63519

RPV Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63519
RPV
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Liposomes
Sequence
RGDPFVYLI
Physicochemical Analysis
C52H78N12O13
ANCEQHKMSTW
RDGILFPYV
1079.26
6.71
1
1
5
-0
-0.37
0.444
118.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
138.06
1
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
9
C52H78N12O13
1079.26
6.71
-0
-0.37
0.444
Free
Liposomes
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Nsclc A549 Cells

Assay & Model

Tumor-bearing nude mice (Male BALB/c nude mice, weighing 20 ± 2 g)
Tumor-bearing nude mice (Male BALB/c nude mice, weighing 20 ± 2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Epirubicin and Dioscin
Cellular Membrane And The Nuclei
Order of fluorescence intensity: free epirubicin >RPV-modified epirubicin and dioscin co-delivery liposomes >epirubicin and dioscin co-delivery liposomes ≥epirubicin liposomes
In vitro and in vivo
CTTCC
Additional Detail Fields 1 fields
CTTCC