Back to search

Peptide record

TPDB63516

RGD Peptide Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63516
RGD Peptide
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
RGDFC
Physicochemical Analysis
C24H36N8O8S1
ANEQHILKMPSTWYV
RDCGF
596.66
6.09
1
1
1
-0
0.68
-0.620
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
1
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C24H36N8O8S1
596.66
6.09
-0
0.68
-0.620
RGD
Evidence Records 3 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor cell, Tumor vessel
Targeting
Breast cancer, Colon cancer, Pancreatic ductal adenocarcinoma
αvβ6

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nano-enabled immunotherapy in cancer
2022
US 11433143 B2
US 11433143 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell
BALB/c mice
Phage display library
PEGylated cholesterol , indoximod
Cyclic
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Ovarian cancer, non-small cell Lung cancer, Breast cancer
integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery
2016
D.H. Nguyen et al. Acta Biomaterialia. 2016 April 15. Pages 109-117

Other

HeLa cells
beta-cyclodextrin, polyethylene glycol (PEG), paclitaxel (PTX)
Cyclic
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging
2012
Shilei Zhu et al. Anal Chim Acta. 2013 Jan 3:758:138-44.

Other

MDA-MB-231 breast cancer cell line
BODIPY polymeric dye
Cyclic
Additional Detail Fields 3 fields
PEGylated cholesterol , indoximod beta-cyclodextrin, polyethylene glycol (PEG), paclitaxel (PTX) BODIPY polymeric dye
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell HeLa cells MDA-MB-231 breast cancer cell line
BALB/c mice