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Peptide record

TPDB63503

ultrashort peptide 3 Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB63503
ultrashort peptide 3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 4-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Biotinylation
Sequence
RFFR
Physicochemical Analysis
C30H44N10O5
ANDCEQGHILKMPSTWYV
RF
624.74
12.40
2
0
2
+2
-0.64
-0.850
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C30H44N10O5
624.74
12.40
+2
-0.64
-0.850
Free
L
Cationic
Linear
Biotinylation
N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hacat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
R-phycoerythrin-streptavidin
Cytoplasm(More) And Nucleus(Less)
Biotin-RFFR show 40% internalization of that observed for the TAMRA-RFFR construct in HaCaT keratinocytes cells.
Endocytosis
In vitro
CCCC
Additional Detail Fields 1 fields
CCCC