TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63501

Peptide_Name

REDV-TAT-NLS-H12

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 34-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

Chemical: Micelles

Sequence

REDVYGRKKRRQRRRPKKKRKVHHHHHHHHHHHH

FASTA

>TPDB63501|Cell-penetrating Peptides|length=34
REDVYGRKKRRQRRRPKKKRKVHHHHHHHHHHHH

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

34 reviewed residue count

C_terminal_Modification

Free Activity

Chemical_Modification

Micelles Activity

Chirality

L Activity

Ionic_State

Cationic Activity

Linearity

Linear Activity

N_terminal_Modification

Free Activity

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HUVECs And Huasmcs Cells

Assay & Model

In Vitro Model Male mice (6 weeks old, 20–25 g)

In Vivo Model Male mice (6 weeks old, 20–25 g)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type pZNF583

Subcellular Localization Nucleus And Less In Lysosome

Uptake Efficiency Among all groups, REDV-TAT-NLS-H12/pZNF580 complexes group showed the best transfection result

Uptake Mechanism Clathrin-mediated and other endocytosis pathways

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCSSGGGGTCCCCCCSSSCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HUVECs And Huasmcs Cells

Assay & Model

In Vitro Model Male mice (6 weeks old, 20–25 g)

In Vivo Model Male mice (6 weeks old, 20–25 g)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Cy5-oligonucleotide complexes

Subcellular Localization Nucleus And Less In Lysosome

Uptake Efficiency MFI is nearly 14 folds higher than REDV-TAT-NLS-H0/Cy5 oligonucleotide complexe.

Uptake Mechanism Clathrin-mediated and other endocytosis pathways

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCSSGGGGTCCCCCCSSSCC

DSSP_Secondary_Structure

CCCCSSGGGGTCCCCCCSSSCC