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Peptide record

TPDB63492

DLCC-3 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB63492
DLCC-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RCSSKKSKHCG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C47H85N19O15S2
ANDEQILMFPTWYV
KS
1220.43
10.32
5
0
0
+4
3.90
-1.564
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
0.10
5
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
1
H
0
I
0
L
3
K
0
M
0
F
0
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11 reviewed residue count
C47H85N19O15S2 sequence-only estimate (linear, free termini)
1220.43 sequence-only estimate (linear, free termini)
10.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.90 sequence-only estimate (linear, free termini)
-1.564 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Cyclic Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Abdominal Skin From Male Kunming (Km) Mice

Assay & Model

Male Kunming (KM) mice
Male Kunming (KM) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Triptolide (TP)
Accumulative penetration amount of TP is decreased
In vitro and in vivo
CCCCTTTSCC
Additional Detail Fields 1 fields
CCCCTTTSCC