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Peptide record

TPDB63484

0031_SpyT Cell-penetrating Peptides standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB63484
0031_SpyT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 50-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RASPSEQRRKRRRCHRGETQRPDFEAEIEKQQRGASAHIVMVDAYKPTKG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C244H405N89O75S2
NLW
R
5849.57
10.92
15
7
12
+6
4.37
-1.570
37.20
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
0.25
11
Residue Composition
number
5
A
9
R
0
N
2
D
1
C
5
E
4
Q
3
G
2
H
2
I
0
L
4
K
1
M
1
F
3
P
3
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 5 R: 9 N: 0 D: 2 C: 1 E: 5 Q: 4 G: 3 H: 2 I: 2 L: 0 K: 4 M: 1 F: 1 P: 3 S: 3 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
50 reviewed residue count
C244H405N89O75S2 sequence-only estimate (linear, free termini)
5849.57 sequence-only estimate (linear, free termini)
10.92 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.37 sequence-only estimate (linear, free termini)
-1.570 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Or T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
β-lactamase protein and CCF2-AM cell-permeable dye
Cytoplasm
In vitro
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Additional Detail Fields 1 fields
CCCCCCSSCCSCCSCHHHHHHTGGGCC