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Peptide record

TPDB63473

M5 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63473
M5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
QWQRNMRKVRGPPVSCIKR-NH2
Physicochemical Analysis
C100H171N37O24S2
ADEHLFTY
R
2339.81
12.41
6
0
5
+6
5.35
-1.279
51.05
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5500
235.06
5
Residue Composition
number
0
A
4
R
1
N
0
D
1
C
0
E
2
Q
1
G
0
H
1
I
0
L
2
K
1
M
0
F
2
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 1 L: 0 K: 2 M: 1 F: 0 P: 2 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
19
C100H171N37O24S2
2339.81
12.41
+6
5.35
-1.279
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Vesicles at low concentartion and cytoplasm and nucleus at high concentart
Lower than hLF peptide
In vitro
CCCHHHHTTCCCCSSSCCC
Additional Detail Fields 1 fields
CCCHHHHTTCCCCSSSCCC