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Peptide record

TPDB63471

QTVNL Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63471
QTVNL
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
QTVNLLSDVRRS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C57H102N20O20
ACEGHIKMFPWY
RLSV
1387.56
10.89
2
1
4
+1
3.52
-0.483
113.33
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
2
R
1
N
1
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
12 reviewed residue count
C57H102N20O20 sequence-only estimate (linear, free termini)
1387.56 sequence-only estimate (linear, free termini)
10.89 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
3.52 sequence-only estimate (linear, free termini)
-0.483 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
Moderate uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC