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Peptide record

TPDB63460

No. 2510 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63460
No. 2510
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with fluorescein
Sequence
QQHLLIAINGYPRYN
Physicochemical Analysis
C82H126N24O22
DCEKMFSTWV
NQILY
1800.05
9.63
2
0
7
+1
0.44
-0.527
110.67
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
2980
165.55
6
Residue Composition
number
1
A
1
R
2
N
0
D
0
C
0
E
2
Q
1
G
1
H
2
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 2 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C82H126N24O22
1800.05
9.63
+1
0.44
-0.527
Free
L
Amphipathic
Linear
Conjugation with fluorescein
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Jurkat and CHO

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Fluorophore (fluorescein)
Similar or greater than TAT in CHO cells, Greater
In vitro
CCCCCCCCSCCCCC
Additional Detail Fields 1 fields
CCCCCCCCSCCCCC