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Peptide record

TPDB63436

L3 Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB63436
L3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
PWPRVPWRWGSTSRDHMVLHEYVNAAGIT-NH2
Physicochemical Analysis
C156H228N46O40S1
CQKF
RPWV
3419.87
9.87
5
2
12
+1
2.21
-0.572
63.79
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
17990
526.04
6
Residue Composition
number
2
A
3
R
1
N
1
D
0
C
1
E
0
Q
2
G
2
H
1
I
1
L
0
K
1
M
0
F
3
P
2
S
2
T
3
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 1 L: 1 K: 0 M: 1 F: 0 P: 3 S: 2 T: 2 W: 3 Y: 1 V: 3
Chemical Descriptors
29
C156H228N46O40S1
3419.87
9.87
+1
2.21
-0.572
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, Jurkat E6.1 Leukemia Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
carboxyfluorescein(CF) dye
Cytoplasm
Peptides L3 and L4 showed even less uptake
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC