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Peptide record

TPDB63433

LRRK(21546−1564) Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63433
LRRK(21546−1564)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acylation
Sequence
PVIDRKRLLQLVRENQLQL-NH2
Physicochemical Analysis
C103H183N33O28
ACGHMFSTWY
L
2331.79
11.22
4
2
8
+2
6.31
-0.426
153.68
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
4
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
1
E
3
Q
0
G
0
H
1
I
5
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 3 G: 0 H: 0 I: 1 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C103H183N33O28
2331.79
11.22
+2
6.31
-0.426
Amidation
L
Polycationic
Linear
Acylation
N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

T-Rex HEK-293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Polycationic
Synthetic
TAMRA-labelled at N terminus
Cytosol
TAMRA-LRRK21546-1564 accumulate and strongly co-localise with GFP-tagged LRRK2 protein with co-localisation coefficients (R) of 0.988 ± 0.006.
In vitro
CCCCTTCGGGHHHHCCCCC
Additional Detail Fields 1 fields
CCCCTTCGGGHHHHCCCCC