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Peptide record

TPDB63425

Protamine 2 (proticles 2) Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB63425
Protamine 2 (proticles 2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
PRRRRSSRRPVRRRRRPRVSRRRRRRGGRRRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C170H326N98O36
ANDCEQHILKMFTWY
R
4319.09
13.72
22
0
2
+22
10.26
-3.081
18.12
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
3
Residue Composition
number
0
A
22
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
3
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 22 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
32 reviewed residue count
C170H326N98O36 sequence-only estimate (linear, free termini)
4319.09 sequence-only estimate (linear, free termini)
13.72 sequence-only estimate (linear, free termini)
+22 sequence-only estimate (linear, free termini)
10.26 sequence-only estimate (linear, free termini)
-3.081 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3-L1 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
miRNA-27a Nanoparticle
Cytoplasm
Concentration-dependent internalization
Endocytosis
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC