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Peptide record

TPDB63422

Protamine 4 (proticles 4) Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB63422
Protamine 4 (proticles 4)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
PRRRRASRRIRRRRRPRVSRRRRRGGRRRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C160H309N93O33
NDCEQHLKMFTWY
R
4063.82
13.70
21
0
3
+21
10.25
-2.987
26.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
2
Residue Composition
number
1
A
21
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
0
L
0
K
0
M
0
F
2
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 21 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
30 reviewed residue count
C160H309N93O33 sequence-only estimate (linear, free termini)
4063.82 sequence-only estimate (linear, free termini)
13.70 sequence-only estimate (linear, free termini)
+21 sequence-only estimate (linear, free termini)
10.25 sequence-only estimate (linear, free termini)
-2.987 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3-L1 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
miRNA-27a Nanoparticle
Cytoplasm
Concentration-dependent internalization
Endocytosis
In vitro